Fat tissue: a steroid reservoir and site of steroid metabolism.

  title={Fat tissue: a steroid reservoir and site of steroid metabolism.},
  author={J. P. Deslypere and L J Verdonck and Alex Vermeulen},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={61 3},
Sex steroid concentrations and 17 beta-hydroxy-steroid dehydrogenase and aromatase activities were determined in fat tissue removed at surgery or, in order to allow comparisons in different sites, postmortem. Except for dehydroepiandrosterone (DHEA) sulfate (DHEAS), there existed a positive tissue/plasma gradient for all steroids studied (testosterone, androstenedione, DHEA, androstenediol, estrone, and estradiol), suggesting androgen uptake and estrogen synthesis in situ. Androgen… CONTINUE READING
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