Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.

@article{Zimmermann2004FatMI,
  title={Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.},
  author={Robert Zimmermann and Juliane Gertrude Strauss and Guenter Haemmerle and Gabriele Schoiswohl and Ruth Birner-Gruenberger and Monika Riederer and Achim Lass and Georg Neuberger and Frank Eisenhaber and Albin Hermetter and Rudolf Zechner},
  journal={Science},
  year={2004},
  volume={306 5700},
  pages={1383-6}
}
Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. Here, we report that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. It is interesting that… CONTINUE READING
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