Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.

  title={Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.},
  author={Li-ping Li and Liqun Zang and Feiran Zhang and Junchen Chen and Hui Shen and Liqi Shu and Feng Liang and Chunyue Feng and Deng Chen and Huikang Tao and Tianlei Xu and Ziyi Li and Yunhee Kang and Hao Wu and Lichun Tang and Pumin Zhang and Peng Jin and Qiang Shu and Xuekun Li},
  journal={Human molecular genetics},
  volume={26 13},
Fat mass and obesity-associated gene (FTO) is a member of the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and intellectual disability. The role of FTO in neurodevelopment and neurogenesis, however, remains largely unknown. Here we show that FTO is expressed in adult neural stem cells and neurons and displays dynamic expression during postnatal neurodevelopment. The loss of FTO leads to decreased brain size and body weight. We find that FTO… CONTINUE READING



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