Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation.

Abstract

We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP(-/-) mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP(-/-) mice. In addition, compared with WD-fed WT mice, ChREBP(-/-) mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.

DOI: 10.1016/j.bbrc.2015.04.092

Cite this paper

@article{Wu2015FatAC, title={Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation.}, author={Wudelehu Wu and Hiromi Tsuchida and Takehiro Kato and Horoyuki Niwa and Yukio Horikawa and Jun Takeda and Katsumi Iizuka}, journal={Biochemical and biophysical research communications}, year={2015}, volume={461 4}, pages={681-6} }