Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans.

@article{Yeo2008FatAF,
  title={Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans.},
  author={Wee Kian Yeo and Sarah J. Lessard and Zhi-ping Chen and Andrew P. Garnham and Louise M. Burke and Donato A. Rivas and Bruce E. Kemp and John A. Hawley},
  journal={Journal of applied physiology},
  year={2008},
  volume={105 5},
  pages={
          1519-26
        }
}
We have previously reported that 5 days of a high-fat diet followed by 1 day of high-carbohydrate intake (Fat-adapt) increased rates of fat oxidation and decreased rates of muscle glycogenolysis during submaximal cycling compared with consumption of an isoenergetic high-carbohydrate diet (HCHO) for 6 days (Burke et al. J Appl Physiol 89: 2413-2421, 2000; Stellingwerff et al. Am J Physiol Endocrinol Metab 290: E380-E388, 2006). To determine potential mechanisms underlying shifts in substrate… 

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