Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.

@article{Xu2015FatSpecificP2,
  title={Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.},
  author={Ming-Jiang Xu and Yan Cai and Hua Wang and Jos{\'e} S. Altamirano and Binxia Chang and Adeline Bertola and Gemma {\`O}dena and Jim Z Lu and Naoki Tanaka and Kimihiko Matsusue and Tsutomu Matsubara and Partha Mukhopadhyay and Shioko Kimura and P{\'a}l Pacher and Frank J. Gonzalez and Ram{\'o}n Bataller and Bin Gao},
  journal={Gastroenterology},
  year={2015},
  volume={149 4},
  pages={1030-41.e6}
}
BACKGROUND & AIMS Alcoholic steatohepatitis (ASH) is the progressive form of alcoholic liver disease and may lead to cirrhosis and hepatocellular carcinoma. We studied mouse models and human tissues to identify molecules associated with ASH progression and focused on the mouse fat-specific protein 27 (FSP-27)/human cell death-inducing DFF45-like effector C (CIDEC) protein, which is expressed in white adipose tissues and promotes formation of fat droplets. METHODS C57BL/6N mice or mice with… CONTINUE READING