Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

@article{Zimmermann2004FatMI,
  title={Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase},
  author={R. Zimmermann and J. Strauss and G. Haemmerle and Gabriele Schoiswohl and R. Birner-Gruenberger and M. Riederer and A. Lass and Georg Neuberger and F. Eisenhaber and A. Hermetter and R. Zechner},
  journal={Science},
  year={2004},
  volume={306},
  pages={1383 - 1386}
}
  • R. Zimmermann, J. Strauss, +8 authors R. Zechner
  • Published 2004
  • Medicine, Biology
  • Science
  • Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. Here, we report that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. It is interesting that… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Diabetes mellitus type I (DM I) is characterized by lack of endogenous insulin and these patients are 100% dependent on insulin substitution to survive. Insulin is a potent… Expand
    ConditionsDiabetes Mellitus Type I, Ketoacidosis
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    Hypothesis 1. To define whether stimulation of ATGL and suppression of G0/G1 switch gene occur in the initial phases of diabetic ketoacidosis and thus can be identified as… Expand
    ConditionsDiabetes Mellitus Type 1, Ketoacidosis
    InterventionBiological
    Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
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    Hormonal Regulation of Lipolysis in Adipose Tissue
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    Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A
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    Adipocyte lipases and defect of lipolysis in human obesity.
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