Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice.

@article{Hu2015FasudilPC,
  title={Fasudil prevents calcium oxalate crystal deposit and renal fibrogenesis in glyoxylate-induced nephrolithic mice.},
  author={Hai-yan Hu and Wei Chen and Jiarong Ding and Meng Jia and Jingjing Yin and Zhiyong Guo},
  journal={Experimental and molecular pathology},
  year={2015},
  volume={98 2},
  pages={277-85}
}
Nephrolithiasis is a common kidney disease and one of the major causes of chronic renal insufficiency. We develop and utilize a glyoxylate induced mouse model of kidney calcium oxalate crystal deposition for studying the pharmacological effects of fasudil, a Rho associated protein kinase (ROCK) specific inhibitor, on the kidney injury and fibrosis caused by calcium oxalate crystallization and deposition. Glyoxylate was administrated intraperitoneally to C57BL/6J mice for five consecutive days… CONTINUE READING
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