Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

@inproceedings{Bowerman2012FasudilIS,
  title={Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy},
  author={Melissa Bowerman and Lyndsay M Murray and Justin Boyer and Carrie L. Anderson and Rashmi Kothary},
  booktitle={BMC medicine},
  year={2012}
}
BACKGROUND Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (SMN1) gene and is typified by the loss of spinal cord motor neurons, muscular atrophy, and in severe cases, death. The SMN protein is ubiquitously expressed and various cellular- and tissue-specific… CONTINUE READING