Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.

@article{Kumai2007FasudilAS,
  title={Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.},
  author={Toshio Kumai and Yuko Takeba and Naoki Matsumoto and Sachiko Nakaya and Yoshimitsu Tsuzuki and Yohei Yanagida and Mikito Hayashi and Shinichi Kobayashi},
  journal={Life sciences},
  year={2007},
  volume={81 15},
  pages={1193-8}
}
We investigated the effects of fasudil, a Rho kinase inhibitor, on hypertension in spontaneously hypertensive rats and on the catecholamine synthetic pathway. Ten-week-old male SHR and Wistar-Kyoto rats were administered fasudil (10 mg/kg/day s.c.) for 4 days. Systolic blood pressure was measured using the tail-cuff method. Catecholamine levels were measured with high-performance liquid chromatography-ECD methods. Tyrosine hydroxylase protein levels were measured in Western blot analysis. The… CONTINUE READING
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