Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.

Abstract

BACKGROUND In this study, we tested the hypothesis that long-term Rho-kinase inhibition would reverse nitro-L-arginine methyl ester-exacerbated nephrosclerosis in spontaneously hypertensive rats and attempted to elucidate the mechanism involved. METHODS Five groups (each n = 8) were studied: untreated spontaneously hypertensive rats; nitro-L-arginine… (More)
DOI: 10.1097/HJH.0b013e328305086c

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@article{Koshikawa2008FasudilAR, title={Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.}, author={Shogo Koshikawa and Toshio Nishikimi and Chikako Inaba and Kazumi Akimoto and Hiroaki Matsuoka}, journal={Journal of hypertension}, year={2008}, volume={26 9}, pages={1837-48} }