Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment

@article{TownesAnderson2017FasudilAC,
  title={Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment},
  author={E. Townes-Anderson and J. Wang and {\'E}. Hal{\'a}sz and I. Sugino and Amy Pitler and I. Whitehead and M. Zarbin},
  journal={Translational Vision Science & Technology},
  year={2017},
  volume={6}
}
  • E. Townes-Anderson, J. Wang, +4 authors M. Zarbin
  • Published 2017
  • Medicine, Chemistry, Biology
  • Translational Vision Science & Technology
  • Purpose Retinal detachment disrupts the rod-bipolar synapse in the outer plexiform layer by retraction of rod axons. We showed that breakage is due to RhoA activation whereas inhibition of Rho kinase (ROCK), using Y27632, reduces synaptic damage. We test whether the ROCK inhibitor fasudil, used for other clinical applications, can prevent synaptic injury after detachment. Methods Detachments were made in pigs by subretinal injection of balanced salt solution (BSS) or fasudil (1, 10 mM). In some… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 51 REFERENCES
    RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment
    10
    Apoptotic photoreceptor degeneration in experimental retinal detachment.
    327
    Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy.
    154
    Neurite outgrowth from bipolar and horizontal cells after experimental retinal detachment.
    184
    ROCK inhibitors in ocular disease
    1