Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment

@inproceedings{TownesAnderson2017FasudilAC,
  title={Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment},
  author={Ellen Townes-Anderson and Jianfeng Wang and {\'E}va Hal{\'a}sz and Ilene K. Sugino and Amy Pitler and Ian Whitehead and Marco Attilio Zarbin},
  booktitle={Translational vision science & technology},
  year={2017}
}
PURPOSE Retinal detachment disrupts the rod-bipolar synapse in the outer plexiform layer by retraction of rod axons. We showed that breakage is due to RhoA activation whereas inhibition of Rho kinase (ROCK), using Y27632, reduces synaptic damage. We test whether the ROCK inhibitor fasudil, used for other clinical applications, can prevent synaptic injury after detachment. METHODS Detachments were made in pigs by subretinal injection of balanced salt solution (BSS) or fasudil (1, 10 mM). In… CONTINUE READING
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