Fasting plasma peptide-YY concentrations are elevated but do not rise postprandially in type 2 diabetes

@article{English2006FastingPP,
  title={Fasting plasma peptide-YY concentrations are elevated but do not rise postprandially in type 2 diabetes},
  author={Patrick J. English and Anthony T Ashcroft and Michael Ty Patterson and Terence Michael Dovey and Jason C. G. Halford and Jean Harrison and Donald Eccleston and Stephen R. Bloom and Mohamed A Ghatei and John P H Wilding},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={2219-2221}
}
To the Editor: Weight loss appears to be particularly difficult to achieve in patients with type 2 diabetes compared to their non-diabetic counterparts [1]. The hormones peptide YY3–36 (PYY) and ghrelin are implicated in the regulation of appetite, energy balance and the pathophysiology of obesity. PYY is released from L-cells in the gut in response to food [2]. Fasting concentrations are lower and postprandial responses attenuated in obese subjects [3], and infusions of PYY to mimic the… CONTINUE READING
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