Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways.

@article{Lin2007FastingIT,
  title={Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways.},
  author={Shu Lin and En-Ju D. Lin and Dana Boey and Nicola J Lee and Katy Slack and Matthew John During and Amanda Sainsbury and Herbert Herzog},
  journal={Endocrinology},
  year={2007},
  volume={148 5},
  pages={
          2056-65
        }
}
Neuropeptide Y, a neuropeptide abundantly expressed in the brain, has been implicated in the regulation of the hypothalamo-pituitary-somatotropic axis and the hypothalamo-pituitary-gonadotropic axis. Elevated hypothalamic neuropeptide Y expression, such as that occurs during fasting, is known to inhibit both of these axes. However, it is not known which Y receptor(s) mediate these effects. Here we demonstrate, using Y receptor knockout mice, that Y2 and Y4 receptors are separately involved in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Role of the hypothalamus in the neuroendocrine regulation of body weight and composition during energy deficit.

  • Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2012
VIEW 3 EXCERPTS

Y2 and Y4 receptor signaling synergistically act on energy expenditure and physical activity.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2010
VIEW 3 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 68 REFERENCES

Effect of growth hormone therapy on serum adiponectin and resistin levels in short SGA children and associations with cardiovascular risk parameters

R Willemsen, M vanDijk, +3 authors A Hokken-Koelega
  • J Clin Endocrinol Metab
  • 2007

Efficacy and safety of growth hormone (GH) in the treatment of adult Japanese patients with GH deficiency: a randomised, placebo-controlled study.

  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2006