Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways.

@article{Lin2007FastingIT,
  title={Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways.},
  author={Shu Lin and En-Ju D. Lin and Dana Boey and Nicola J. Lee and Katy Slack and Matthew John During and Amanda Sainsbury and Herbert Herzog},
  journal={Endocrinology},
  year={2007},
  volume={148 5},
  pages={2056-65}
}
Neuropeptide Y, a neuropeptide abundantly expressed in the brain, has been implicated in the regulation of the hypothalamo-pituitary-somatotropic axis and the hypothalamo-pituitary-gonadotropic axis. Elevated hypothalamic neuropeptide Y expression, such as that occurs during fasting, is known to inhibit both of these axes. However, it is not known which Y receptor(s) mediate these effects. Here we demonstrate, using Y receptor knockout mice, that Y2 and Y4 receptors are separately involved in… CONTINUE READING