Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner.

@article{Nishio2012FastingIC,
  title={Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner.},
  author={Shin-Ichi Nishio and Yann Gibert and Liubov Berekelya and Laure Bernard and Fr{\'e}d{\'e}ric Brunet and Etienne Guillot and Jean-Christophe Le Bail and Juan Antonio Sanchez and Anne Marie Galzin and G{\'e}rard Triqueneaux and Vincent Laudet},
  journal={Molecular endocrinology},
  year={2012},
  volume={26 8},
  pages={
          1316-26
        }
}
Central and peripheral mechanisms modulate food intake and energy balance in mammals and the precise role of the type 1 cannabinoid receptor (CB1) in these processes is still being explored. Using the zebrafish, Danio rerio, we show that rimonabant, a CB1-specific antagonist with an EC(50) of 5.15 × 10(-8) m, decreases embryonic yolk sac reserve use. We reveal a developmental overlap between CART genes and CB1 expression in the hypothalamus and medulla oblongata, two brain structures that play… CONTINUE READING
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