Fasting-induced changes in the hypothalamus-pituitary-thyroid axis.

  title={Fasting-induced changes in the hypothalamus-pituitary-thyroid axis.},
  author={Anita Boelen and Wilmar Maarten Wiersinga and Eric Fliers},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={18 2},
Fasting induces profound changes in the hypothalamus-pituitary-thyroid (HPT) axis. The alterations observed in humans and rodents are similar in many ways, although they may be more pronounced and more acute in rodents. The molecular mechanisms underlying the resetting of HPT axis regulation in the framework of caloric deprivation are still incompletely understood. Fascinating studies in rats and mice have shown a dramatic downregulation of thyrotropin-releasing hormone (TRH) gene expression in… CONTINUE READING
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