Fasting in mood disorders: neurobiology and effectiveness. A review of the literature

  title={Fasting in mood disorders: neurobiology and effectiveness. A review of the literature},
  author={Guillaume Fond and Alexandra Macgregor and Marion Leboyer and Andreas Michalsen},
  journal={Psychiatry Research},

Tables from this paper

Fasting in mood disorders and its potential therapeutic aspects -narrative review
Dietary restriction and fasting are promising methods in co-therapy of mood disorders treatment, however, implementing therapy needs earlier individual evaluation of their benefits and risk, the same as patient’s feasibility of implementing this type of intervention.
Improving diet for psychiatric patients : High potential benefits and evidence for safety.
Fasting Interventions for Stress, Anxiety and Depressive Symptoms: A Systematic Review and Meta-Analysis
These results are preliminary and encouraging and fasting appears to be a safe intervention and further trials should be carried out in psychiatric populations that may be good candidates for fasting interventions.
The Effects of Calorie Restriction in Depression and Potential Mechanisms
Dual effects of calorie restriction in depression and potential molecular basis behind these effects, especially focusing on antidepressant effects are reviewed.
[Fasting - Effects on the Human Body and Psyche].
This pilot study showed a wide range of effects and remarkable interindividual variation in the possible effects of fasting on body and well-being/psychic features.
Is diet important in bipolar disorder?
For patients, the supplementation of mood disorders treatment with dietary recommendations, supplementation with selected nutrients, supplementation of micronutrients, may provide the possibility of greater co-participation in the treatment, enhancing the sense of control, coping, which may have a significant effect on the course of BD and the effectiveness of its treatment.
How Does Fasting Affect Cognition? An Updated Systematic Review (2013–2020)
Review of studies indicated that fasting was associated with deficits in cognitive function; few studies indicated a benefit in cognitive functioning following a single voluntary fast.
Ramadan Fasting Improves Body Composition without Exacerbating Depression in Males with Diagnosed Major Depressive Disorders
RF did not negatively affect depressive symptoms and improved body composition, suggesting short-term intermittent fasting may be a safe dietary practice for adult males with MDD.
Decreased anxiety after Dawood fasting in the pre-elderly and elderly
The fast of Dawood reduced anxiety in the pre-elderly and elderly and there was an increase in the QOL of the fasting group, although no significant difference was found when compared to the non-fasting group.


Prolonged Fasting as a Method of Mood Enhancement in Chronic Pain Syndromes: A Review of Clinical Evidence and Mechanisms
  • A. Michalsen
  • Medicine, Psychology
    Current pain and headache reports
  • 2010
Fasting treatments may be useful as an adjunctive therapeutic approach in chronic pain patients and the mood-enhancing and pain-relieving effect of therapeutic fasting should be further evaluated in randomized clinical trials.
Prolonged fasting in patients with chronic pain syndromes leads to late mood-enhancement not related to weight loss and fasting-induced leptin depletion
It is suggested that fasting induces specific mood-enhancement and the physiological mediator appears to be neither leptin nor cortisol, the role of other mechanisms has to be further studied.
Effect of fasting during Ramadan on serum lithium level and mental state in bipolar affective disorder
Fasting in an average temperature of 28°C for up to 12 h per day did not result in elevated serum lithium levels or more side effects and did not have adverse effects on mental state of patients suffering from bipolar affective disorder.
The Short-term Effects of Fasting on the Neuroendocrine System in Patients with Chronic Pain Syndromes
The results show that short-term fasting leads to neuroendocrine activation and may suggest that the extent of this response is dependent on the individual metabolic and endocrine state at baseline.
Appetite regulation by serotoninergic mechanisms and effects of d-fenfluramine.
  • E. L. Noach
  • Biology, Psychology
    The Netherlands journal of medicine
  • 1994
Evidence is presented for the theory that the neurotransmitter, serotonin, in medial hypothalamic centres is an important regulator for appetite and for the selection of major food constituents, and it is presumed that in the treatment of obesity, successes with reducing diets may be enhanced by including periods of high-carbohydrate, low-protein intake.
Ramadan fasting and inflammatory bowel disease.
It appears that Ramadan fasting does not impose serious risks on patients with IBD, and there was no correlation between the number of fasting days and the severity of the disease, QoL and psychological state of the patients.
Hunger and Mood during Extended Fasting Are Dependent on the GNB3 C825T Polymorphism
The strong association between the subjective response to fasting with GNB3 genotypes indicates a role of the gene in the behavioural regulation of food intake, which should be further considered in nutritional intervention studies.
Effects of fasting therapy on irritable bowel syndrome
The results suggest that FT may have beneficial effects on intractable patients with IBS, and the control therapy significantly improved only 3 out of the 10 symptoms assessed.
Endocrine disturbances in depression
There is increasing evidence that leptin and neurosteroids, such as DHEA, are implicated in mood disorders, and CRH and AVP are likely to play a substantial role in the pathophysiology of this disorder.