Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase.

@article{Wu2012FastingEH,
  title={Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase.},
  author={Jiang Wei Wu and Shu Wang and St{\'e}phanie Casavant and Alain Moreau and Gong She Yang and Grant A Mitchell},
  journal={Endocrinology},
  year={2012},
  volume={153 5},
  pages={
          2198-207
        }
}
Adipose triglyceride lipase (ATGL) catalyzes the first step of lipolysis of cytoplasmic triacylglycerols in white adipose tissue (WAT) and several other organs. We created adipose-specific ATGL-deficient (ATGLAKO) mice. In these mice, in vivo lipolysis, measured as the increase of plasma nonesterified fatty acid and glycerol levels after injection of a β3-adrenergic agonist, was undetectable. In isolated ATGLAKO adipocytes, β3-adrenergic-stimulated glycerol release was 10-fold less than in… CONTINUE READING
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