Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin1.

@article{Mizuno1999FastingRH,
  title={Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin1.},
  author={Tooru M. Mizuno and Hideo Makimura and Jeffrey Silverstein and James L. Roberts and Tina Lopingco and Charles Vernon Mobbs},
  journal={Endocrinology},
  year={1999},
  volume={140 10},
  pages={4551-4557}
}
Fasting increases hypothalamic neuropeptide Y (NPY) and agoutirelated peptide (AGRP) messenger RNA (mRNA) and reduces hypothalamic POMC mRNA, and is also characterized by a reduction in plasma leptin, insulin, and glucose, each of which has been implicated in the regulation of hypothalamic gene expression. To further evaluate the roles of leptin, insulin, and glucose in mediating effects of fasting, we examined hypothalamic gene expression in nondiabetic and streptozotocin (STZ)-induced… CONTINUE READING