Fasting Plasma Glucose Test at the First Prenatal Visit as a Screen for Gestational Diabetes

@article{Sacks2003FastingPG,
  title={Fasting Plasma Glucose Test at the First Prenatal Visit as a Screen for Gestational Diabetes},
  author={David A. Sacks and Wansu Chen and Girma Wolde-Tsadik and Thomas A. Buchanan},
  journal={Obstetrics \& Gynecology},
  year={2003},
  volume={101},
  pages={1197–1203}
}
OBJECTIVE To determine whether the fasting plasma glucose test administered at the first prenatal visit could serve as an efficient screen for gestational diabetes. METHODS A total of 5557 women not known to have diabetes were offered a fasting plasma glucose test at their first prenatal visit. Results less than 100 mg/dL were blinded. A glucose tolerance test was requested immediately of those whose screening test result was 100–125 mg/dL and of all women not identified as having diabetes by… Expand
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TLDR
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TLDR
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TLDR
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TLDR
Using a FPG cut-off to diagnose GDM and to determine the need for post-load OGTT measurements is a valid strategy to diagnoseGDM by IADPSG criteria and may improve feasibility of applying IadPSG diagnostic criteria by reducing costs and increasing convenience. Expand
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TLDR
FPG values which are within the normoglycaemic range constitute an independent risk factor for the development of GDM and the threshold for gestational diabetes diagnosis must be revised. Expand
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TLDR
Only higher fasting glucose levels in early pregnancy, within the normoglycemic range, would predict the development of glucose intolerance with limited sensitivity and specificity. Expand
Fasting capillary glucose as a screening test for ruling out gestational diabetes mellitus.
TLDR
It is hypothesized that measurement of fasting capillary glucose (FCG) could provide a strategy for reducing the number of unnecessary OGTTs, and a threshold level of FCG was sought below which GDM could be ruled out following a positive GCT, without need for the OGTT. Expand
First-trimester fasting plasma glucose as a predictor of gestational diabetes mellitus and the association with adverse pregnancy outcomes
TLDR
Higher first-trimester FPG increased the prevalence of GDM, large for gestational age (LGA) and assisted vaginal delivery and/or cesarean section and FPG at first trimester was associated with adverse pregnancy outcomes. Expand
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TLDR
Plasma insulin and adiponectin concentrations, when measured at 11 weeks, may be predictive of impending gestational diabetes, and further studies are warranted to determine the reliability of these biomarkers. Expand
Fasting plasma glucose and body mass index during the first trimester of pregnancy as predictors of gestational diabetes mellitus in a Chinese population.
TLDR
FPG and BMI combined markedly enhanced the predictive capability for GDM, and high FPG or BMI in the first trimester, especially in combination, may predict later GDM with limited accuracy and specificity in Chinese women. Expand
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Fasting plasma glucose is a useful test for the screening of both subcategories of gestational diabetes, a threshold of 85mg/dl being an acceptable option and effective screening for the subcategory diabetes can be achieved using a cut point of 89 mg/dl. Expand
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Early gestational glucose screening may be beneficial in detecting gestational diabetes in patients over 30 years old who are black or who have risk factors for diabetes, and consideration should be given to repeat glucose testing in the early third trimester in patients with false positive early one-hour screening tests. Expand
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The correlation between the plasma glucose level obtained following a glucose challenge test and the fasting plasma glucoselevel in the first trimester is low, indicating that fasting glucose measurement early in pregnancy has no clinical benefits. Expand
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TLDR
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TLDR
In the absence of a meaningful threshold relationship between glucose tolerance test values and clinical outcome, criteria defining gestational diabetes will probably be established by consensus. Expand
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TLDR
The effect of these two conditions on the and specificity of the screening test is described, and it is suggested that the threshold for glucose tolerance testing be 130 mg/dl if the test is administered in the fed state. Expand
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The interpretation of the glucose tolerance tests during pregnancy, either to detect gestational diabetes or hypoglycemia, should take these physiologic changes into account. Expand
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