Fast whole-brain three-dimensional macromolecular proton fraction mapping in multiple sclerosis.

@article{Yarnykh2015FastWT,
  title={Fast whole-brain three-dimensional macromolecular proton fraction mapping in multiple sclerosis.},
  author={Vasily L. Yarnykh and J D Bowen and Alexey Samsonov and P Repovic and A Mayadev and Peiqing Qian and B Gangadharan and Bart Keogh and Kenneth R. Maravilla and L K Jung Henson},
  journal={Radiology},
  year={2015},
  volume={274 1},
  pages={210-20}
}
PURPOSE To evaluate the clinical utility of fast whole-brain macromolecular proton fraction ( MPF macromolecular proton fraction ) mapping in multiple sclerosis ( MS multiple sclerosis ) and compare MPF macromolecular proton fraction with established quantitative magnetic resonance (MR) imaging measures of tissue damage including magnetization transfer ( MT magnetization transfer ) ratio and relaxation rate (R1). MATERIALS AND METHODS In this institutional review board-approved and HIPAA… CONTINUE READING

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Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
EDSS Expanded Disability Status Scale and MSFC MS functional composite demonstrated strongest correlations with MPF macromolecular proton fraction in GM gray matter ( r = -0.74 and 0.81 ; P < .001 ) followed by WM white matter ( r = -0.57 and 0.72 ; P < .01 ) and lesions ( r = -0.42 and 0.50 ; P < .05 ) .
MPF macromolecular proton fraction in SPMS secondary progressive MS was reduced relative to RRMS relaxing - remitting MS in WM white matter , GM gray matter , and lesions by 6.4% ( P
RRMS relaxing - remitting MS patients had lower WM white matter and GM gray matter MPF macromolecular proton fraction than controls , with percentage decreases of 6.5% ( P
Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
RRMS relaxing - remitting MS patients had lower WM white matter and GM gray matter MPF macromolecular proton fraction than controls , with percentage decreases of 6.5% ( P
MPF macromolecular proton fraction in SPMS secondary progressive MS was reduced relative to RRMS relaxing - remitting MS in WM white matter , GM gray matter , and lesions by 6.4% ( P
Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
Mean MPF macromolecular proton fraction , R1 , and MT magnetization transfer ratio in normal - appearing white matter ( WM white matter ) , gray matter ( GM gray matter ) , and lesions were compared between subject groups by using analysis of variance .
EDSS Expanded Disability Status Scale and MSFC MS functional composite demonstrated strongest correlations with MPF macromolecular proton fraction in GM gray matter ( r = -0.74 and 0.81 ; P < .001 ) followed by WM white matter ( r = -0.57 and 0.72 ; P < .01 ) and lesions ( r = -0.42 and 0.50 ; P < .05 ) .
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