Fast vesicle transport in PC12 neurites: velocities and forces

  title={Fast vesicle transport in PC12 neurites: velocities and forces},
  author={David B. Hill and Michael Jonathan Plaza and Keith Bonin and George M Holzwarth},
  journal={European Biophysics Journal},
Although the mechanical behavior of single-motor protein molecules such as kinesin has been carefully studied in buffer, the mechanical behavior of motor-driven vesicles in cells is much less understood. We have tracked single vesicles in neurites of PC12 cells with a spatial precision of ±30 nm and a time resolution of 120 ms. Because the neurites are thin, long, straight, and attached to the surface of planar cover glasses, the velocity of individual vesicles could be measured for times as… CONTINUE READING
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