Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.

@article{Rullas2010FastST,
  title={Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.},
  author={Joaqu{\'i}n N Rullas and Juan Ignacio Garc{\'i}a and Manuela Beltr{\'a}n and P E Cardona and Neus C{\'a}ceres and Jose Garcia-Bustos and {\'I}{\~n}igo Angulo-Barturen},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 5},
  pages={2262-4}
}
Murine models of Mycobacterium tuberculosis infection are essential tools in drug discovery. Here we describe a fast standardized 9-day acute assay intended to measure the efficacy of drugs against M. tuberculosis growing in the lungs of immunocompetent mice. This assay is highly reproducible, allows good throughput, and was validated for drug lead optimization using isoniazid, rifampin, ethambutol, pyrazinamide, linezolid, and moxifloxacin. 
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