Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development.

@article{Wang2007FastSM,
  title={Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development.},
  author={Yingcai Wang and Danuta Szczesna-Cordary and Robert M. Craig and Zoraida Diaz-Perez and Georgianna Guzman and Todd F. Miller and James D. Potter},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 9},
  pages={
          2205-14
        }
}
In skeletal muscle, the myosin molecule contains two sets of noncovalently attached low molecular weight proteins, the regulatory (RLC) and essential (ELC) light chains. To assess the functional and developmental significance of the fast skeletal isoform of the RLC (RLC-f), the murine fast skeletal RLC gene (Mylpf) was disrupted by homologous recombination. Heterozygotes containing an intronic neo cassette (RLC-/+) had approximately one-half of the amount of the RLC-f mRNA compared to wild-type… CONTINUE READING

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