Fast renal trapping of porcine Luteinizing Hormone (pLH) shown by 123I-scintigraphic imaging in rats explains its short circulatory half-life

@article{Klett2003FastRT,
  title={Fast renal trapping of porcine Luteinizing Hormone (pLH) shown by 123I-scintigraphic imaging in rats explains its short circulatory half-life},
  author={Dani{\`e}le Klett and Serge Bernard and François Lecompte and Herv{\'e} Leroux and Thierry Magallon and Alberto J Locatelli and Alain Lepape and Yves Combarnous},
  journal={Reproductive biology and endocrinology : RB&E},
  year={2003},
  volume={1},
  pages={64 - 64}
}
BackgroundSugar moieties of gonadotropins play no primary role in receptor binding but they strongly affect their circulatory half-life and consequently their in vivo biopotencies. In order to relate more precisely hepatic trapping of these glycoproteic hormones with their circulatory half-life, we undertook a comparative study of the distribution and elimination of porcine LH (pLH) and equine CG (eCG) which exhibit respectively a short and a long half-life. This was done first by following… CONTINUE READING

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