Fast on-rates allow short dwell time ligands to activate T cells.

@article{Govern2010FastOA,
  title={Fast on-rates allow short dwell time ligands to activate T cells.},
  author={Christopher C. Govern and Michelle K Paczosa and Arup K. Chakraborty and Eric S. Huseby},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 19},
  pages={
          8724-9
        }
}
Two contrasting theories have emerged that attempt to describe T-cell ligand potency, one based on the t(1/2) of the interaction and the other based on the equilibrium affinity (K(D)). Here, we have identified and studied an extensive set of T-cell receptor (TCR)-peptide-MHC (pMHC) interactions for CD4(+) cells that have differential K(D)s and kinetics of binding. Our data indicate that ligands with a short t(1/2) can be highly stimulatory if they have fast on-rates. Simple models suggest these… CONTINUE READING

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Models for the specific adhesion of cells to cells.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

VIEW 1 EXCERPT

Measuring diffusion and binding kinetics by contact area FRAP.

VIEW 1 EXCERPT