Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin.

@article{Li2005FastNA,
  title={Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin.},
  author={Xiang Li and Davina V Gutierrez and M. Gartz Hanson and Jing Han and Melanie D Mark and Hillel J. Chiel and Peter Hegemann and Lynn T. Landmesser and Stefan Herlitze},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 49},
  pages={17816-21}
}
Techniques for fast noninvasive control of neuronal excitability will be of major importance for analyzing and understanding neuronal networks and animal behavior. To develop these tools we demonstrated that two light-activated signaling proteins, vertebrate rat rhodopsin 4 (RO4) and the green algae channelrhodospin 2 (ChR2), could be used to control neuronal excitability and modulate synaptic transmission. Vertebrate rhodopsin couples to the Gi/o, pertussis toxin-sensitive pathway to allow… CONTINUE READING
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