Fast multi-blind modification search through tandem mass spectrometry.

@article{Na2012FastMM,
  title={Fast multi-blind modification search through tandem mass spectrometry.},
  author={Seungjin Na and Nuno Bandeira and Eunok Paek},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 4},
  pages={M111.010199}
}
With great biological interest in post-translational modifications (PTMs), various approaches have been introduced to identify PTMs using MS/MS. Recent developments for PTM identification have focused on an unrestrictive approach that searches MS/MS spectra for all known and possibly even unknown types of PTMs at once. However, the resulting expanded search space requires much longer search time and also increases the number of false positives (incorrect identifications) and false negatives… CONTINUE READING

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