Fast inactivation in potassium channels: an interplay of cytoplasmic domains.

@article{Sankaranarayanan2009FastII,
  title={Fast inactivation in potassium channels: an interplay of cytoplasmic domains.},
  author={Kavitha Sankaranarayanan and Hyder Usman and Mathew Kuriyan Mathew},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={388 3},
  pages={490-5}
}
Fast inactivation in voltage-gated potassium channels has traditionally been associated exclusively with the N-terminus. Here, we explore the role of the T1 domain using a series of chimeric channels. A chimeric channel, 4N/2, (N-terminus from the rapidly inactivating hKv1.4, and the channel body from the non-inactivating hKv1.2), exhibited slower and… CONTINUE READING