Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries.

@article{Kecili2014FastIO,
  title={Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries.},
  author={Rustem Kecili and Johan F Billing and David Nivhede and B{\"o}rje Sellergren and Anthony T Rees and Ecevit Yilmaz},
  journal={Journal of chromatography. A},
  year={2014},
  volume={1339},
  pages={65-72}
}
This study describes the identification and evaluation of molecularly imprinted polymers (MIPs) for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals. Screening experiments were performed using existing MIP resin libraries to identify resins selective towards those impurities in the presence of model pharmaceutical compounds. A hit resin with a considerable imprinting effect was found in the screening and upon further investigation, the resin was found… CONTINUE READING