Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice

@article{Zong2017FastHM,
  title={Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice},
  author={Weijian Zong and Runlong Wu and M. Li and Yan-Hui Hu and Y. Li and Jinghang Li and Hao Rong and Haitao Wu and Yangyang Xu and Y. Lu and Hongbo Jia and M. Fan and Z. Zhou and Y. Zhang and A. Wang and Liangyi Chen and Heping Cheng},
  journal={Nature Methods},
  year={2017},
  volume={14},
  pages={713-719}
}
  • Weijian Zong, Runlong Wu, +14 authors Heping Cheng
  • Published 2017
  • Biology, Medicine
  • Nature Methods
  • Developments in miniaturized microscopes have enabled visualization of brain activities and structural dynamics in animals engaging in self-determined behaviors. However, it remains a challenge to resolve activity at single dendritic spines in freely behaving animals. Here, we report the design and application of a fast high-resolution, miniaturized two-photon microscope (FHIRM-TPM) that accomplishes this goal. With a headpiece weighing 2.15 g and a hollow-core photonic crystal fiber delivering… CONTINUE READING
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