Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice

@article{Zong2017FastHM,
  title={Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice},
  author={Weijian Zong and Runlong Wu and Mingli Li and Yanhui Hu and Yijun Li and Jinghang Li and Hao Rong and Haitao Wu and Yangyang Xu and Yang Lu and Hongbo Jia and Ming Fan and Zhuan Zhou and Yunfeng Zhang and Aimin Wang and Liangyi Chen and Heping Cheng},
  journal={Nature Methods},
  year={2017},
  volume={14},
  pages={713-719}
}
Developments in miniaturized microscopes have enabled visualization of brain activities and structural dynamics in animals engaging in self-determined behaviors. However, it remains a challenge to resolve activity at single dendritic spines in freely behaving animals. Here, we report the design and application of a fast high-resolution, miniaturized two-photon microscope (FHIRM-TPM) that accomplishes this goal. With a headpiece weighing 2.15 g and a hollow-core photonic crystal fiber delivering… CONTINUE READING
16 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Assembly of a miniature two-photon microscope headpiece

  • W. Zong
  • Protocol Exchange
  • 2017

Similar Papers

Loading similar papers…