Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord.

@article{Gupta2006FastgellingIB,
  title={Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord.},
  author={Dimpy Gupta and Charles Tator and Molly S Shoichet},
  journal={Biomaterials},
  year={2006},
  volume={27 11},
  pages={2370-9}
}
Strategies for spinal cord injury repair are limited, in part, by poor drug delivery techniques. A novel drug delivery system (DDS) is being developed in our laboratory that can provide localized release of growth factors from an injectable gel. The gel must be fast-gelling, non-cell adhesive, degradable, and biocompatible as an injectable intrathecal DDS. A gel that meets these design criteria is a blend of hyaluronan and methylcellulose (HAMC). Unlike other injectable gels, HAMC is already at… CONTINUE READING
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CD44 and hyaluronic acid regulate in vivo iNOS expression and ARTICLE IN PRESS D

  • PV Cabrera, G Blanco, L Alaniz, S Greczanik, M Garcia, E Alvarez
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