Fast dynamic response of the fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses.

@article{Lara2009FastDR,
  title={Fast dynamic response of the fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses.},
  author={Alvaro R Lara and Hilal Taymaz-Nikerel and Mlawule R. Mashego and Walter M. van Gulik and Joseph J. Heijnen and Octavio Tonatiuh Ram{\'i}rez and Wouter A. van Winden},
  journal={Biotechnology and bioengineering},
  year={2009},
  volume={104 6},
  pages={1153-61}
}
The response of Escherichia coli cells to transient exposure (step increase) in substrate concentration and anaerobiosis leading to mixed-acid fermentation metabolism was studied in a two-compartment bioreactor system consisting of a stirred tank reactor (STR) connected to a mini-plug-flow reactor (PFR: BioScope, 3.5 mL volume). Such a system can mimic the situation often encountered in large-scale, fed-batch bioreactors. The STR represented the zones of a large-scale bioreactor that are far… CONTINUE READING

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