Fast cholesterol flip-flop and lack of swelling in skin lipid multilayers

  title={Fast cholesterol flip-flop and lack of swelling in skin lipid multilayers},
  author={Chinmay Das and Massimo G. Noro and Peter D. Olmsted},
Atomistic simulations were performed on hydrated model lipid multilayers that are representative of the lipid matrix in the outer skin (stratum corneum). We find that cholesterol transfers easily between adjacent leaflets belonging to the same bilayer via fast orientational diffusion (tumbling) in the inter-leaflet disordered region, while at the same time there is a large free energy cost against swelling. This fast flip-flop may play an important role in accommodating the variety of… 

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