Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates

@article{Turcot2000FastBI,
  title={Fast biological iron chelators: kinetics of iron removal from human diferric transferrin by multidentate hydroxypyridonates},
  author={Isabelle Turcot and Alain Stintzi and Jide Xu and Kenneth N Raymond},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2000},
  volume={5},
  pages={634-641}
}
For decades, desferrioxamine B (Desferal) has been the therapeutic iron chelator of choice for iron-overload treatment, despite numerous problems associated with its use. Consequently, there is a continuous search for new iron chelating agents with improved properties, particularly oral activity. We have studied new potential therapeutic iron sequestering… CONTINUE READING