Fast and slow steps in the activation of sodium channels

  title={Fast and slow steps in the activation of sodium channels},
  author={Clay Armstrong and William F. Gilly},
  journal={The Journal of General Physiology},
  pages={691 - 711}
Kinetic features of sodium conductance (gNa) and associated gating current (Ig) were studied in voltage-clamped, internally perfused squid axons. Following a step depolarization Ig ON has several kinetic components: (a) a rapid, early phase largely preceding gNa turn-on; (b) a delayed intermediate component developing as gNa increases; and (c) a slow component continuing after gNa is fully activated. With small depolarizations the early phase shows a quick rise (less than 40 mus) and smooth… CONTINUE READING