Fast and slow steps in the activation of sodium channels

@article{Armstrong1979FastAS,
  title={Fast and slow steps in the activation of sodium channels},
  author={Clay Armstrong and William F. Gilly},
  journal={The Journal of General Physiology},
  year={1979},
  volume={74},
  pages={691 - 711}
}
Kinetic features of sodium conductance (gNa) and associated gating current (Ig) were studied in voltage-clamped, internally perfused squid axons. Following a step depolarization Ig ON has several kinetic components: (a) a rapid, early phase largely preceding gNa turn-on; (b) a delayed intermediate component developing as gNa increases; and (c) a slow component continuing after gNa is fully activated. With small depolarizations the early phase shows a quick rise (less than 40 mus) and smooth… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

On the slowly rising phase of the sodium gating current in the squid giant axon.

  • Proceedings. Biological sciences
  • 1998
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Ionic channels in mouse astrocytes in culture.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
VIEW 4 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Sodium channel activation in the squid giant axon. Steady state properties

  • The Journal of general physiology
  • 1985
VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 17 REFERENCES

Gating currents and charge movements in excitable membranes.

  • Reviews of physiology, biochemistry and pharmacology
  • 1978
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

and closing of the activation gates of the Na channels

W. Almers, C. M. Armstrong
  • J. Gen. Physiol. 63:533-552
  • 1980

Inactivation of the asymmetrical displacement current in giant axons of Loligo forbesi

H. MErEs, W. VOGEL
  • J. Physiol. (Lond.)
  • 1977

Inactivation of the sodium channel. I

F. BEZANILL, C. M. AaMSTRONC
  • Sodium current experiments. J. Gen. Physiol
  • 1977

b. Slow recovery of sodium current and gating current from inactivation

H. Meres, W. VOGEL
  • J. Physiol. (Lond.)
  • 1977

Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH.

  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1975
VIEW 1 EXCERPT