Fast and effective prediction of microRNA/target duplexes.

  title={Fast and effective prediction of microRNA/target duplexes.},
  author={Marc Rehmsmeier and Peter Steffen and Matthias Hochsmann and Robert Giegerich},
  volume={10 10},
MicroRNAs (miRNAs) are short RNAs that post-transcriptionally regulate the expression of target genes by binding to the target mRNAs. Although a large number of animal miRNAs has been defined, only a few targets are known. In contrast to plant miRNAs, which usually bind nearly perfectly to their targets, animal miRNAs bind less tightly, with a few nucleotides being unbound, thus producing more complex secondary structures of miRNA/target duplexes. Here, we present a program, RNA-hybrid, that… CONTINUE READING
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