Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis.

  title={Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis.},
  author={Kristopher Opron and Kelin Xia and Guowei Wei},
  journal={The Journal of chemical physics},
  volume={140 23},
Protein structural fluctuation, typically measured by Debye-Waller factors, or B-factors, is a manifestation of protein flexibility, which strongly correlates to protein function. The flexibility-rigidity index (FRI) is a newly proposed method for the construction of atomic rigidity functions required in the theory of continuum elasticity with atomic rigidity, which is a new multiscale formalism for describing excessively large biomolecular systems. The FRI method analyzes protein rigidity and… 
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