Fast and accurate side‐chain topology and energy refinement (FASTER) as a new method for protein structure optimization

@article{Desmet2002FastAA,
  title={Fast and accurate side‐chain topology and energy refinement (FASTER) as a new method for protein structure optimization},
  author={J. Desmet and Jan A. Spriet and Ignace Lasters},
  journal={Proteins: Structure},
  year={2002},
  volume={48}
}
We have developed an original method for global optimization of protein side‐chain conformations, called the Fast and Accurate Side‐Chain Topology and Energy Refinement (FASTER) method. The method operates by systematically overcoming local minima of increasing order. Comparison of the FASTER results with those of the dead‐end elimination (DEE) algorithm showed that both methods produce nearly identical results, but the FASTER algorithm is 100–1000 times faster than the DEE method and scales in… 
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