Fast and Slow Metabolizers of Hoasca

  title={Fast and Slow Metabolizers of Hoasca},
  author={J. Callaway},
  journal={Journal of Psychoactive Drugs},
  pages={157 - 161}
  • J. Callaway
  • Published 2005
  • Medicine
  • Journal of Psychoactive Drugs
  • Abstract Harmine, a major alkaloid in ayahuasca (hoasca), is a selective and reversible inhibitor of the enzyme monoamine oxidase-A (MAO-A). It is also a selective inhibitor of the human cytochrome P450 isozyme 2D6 (CYP 2D6), which metabolizes harmine to a more hydrophilic derivative for eventual excretion. CYP 2D6 exhibits a wide range of polymorphisms in human populations, and variations in this enzymatic activity could account for differences in effects between individuals who use hoasca… CONTINUE READING

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