Fast Removal of Synaptic Glutamate by Postsynaptic Transporters

@article{Auger2000FastRO,
  title={Fast Removal of Synaptic Glutamate by Postsynaptic Transporters},
  author={C{\'e}line Auger and David Attwell},
  journal={Neuron},
  year={2000},
  volume={28},
  pages={547-558}
}
Glutamate transporters are believed to remove glutamate from the synaptic cleft only slowly because they cycle slowly. However, we show that when glutamate binds to postsynaptic transporters at the cerebellar climbing fiber synapse, it evokes a conformation change and inward current that reflect glutamate removal from the synaptic cleft within a few milliseconds, a time scale much faster than the overall cycle time. Contrary to present models, glutamate removal does not require binding of an… CONTINUE READING
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