Fast Potentiation of Glycine Receptor Channels by Intracellular Calcium in Neurons and Transfected Cells

@article{Fucile2000FastPO,
  title={Fast Potentiation of Glycine Receptor Channels by Intracellular Calcium in Neurons and Transfected Cells},
  author={Sergio Fucile and Didier De Saint Jan and Lia Prado de Carvalho and Piotr Bregestovski},
  journal={Neuron},
  year={2000},
  volume={28},
  pages={571-583}
}
Inhibitory glycine receptors (GlyRs) are mainly expressed in the spinal cord and in the midbrain, where they control motor and sensory pathways. We describe here a fast potentiation of GlyR by intracellular Ca2+. This phenomenon was observed in rat spinal cord neurons and in transfected human cell lines. Potentiation develops in <100 ms, is proportional to Ca2+ influx, and is characterized by an increase in GlyR apparent affinity for glycine. Phosphorylation and G protein pathways appear not to… CONTINUE READING
39 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Modulation of A-type potassium channels

  • J. W. Hinson, K. I. Mattsson, B. W. Strassle, J. S. Trimmer, K. J. Rhodes
  • a family of calcium sensors
  • 2000

Cloning and expression of a novel member of the low voltage activated T-type Wang, R.A., and Randic, M

  • U. Klšckner, T. Schneider, E. Perez-Reyes
  • 1999

Similar Papers

Loading similar papers…