Fast Modulation of Visual Perception by Basal Forebrain Cholinergic Neurons

@article{Pinto2013FastMO,
  title={Fast Modulation of Visual Perception by Basal Forebrain Cholinergic Neurons},
  author={L. Pinto and Michael J. Goard and Daniel Estandian and M. Xu and A. Kwan and Seung-Hee Lee and Thomas C. Harrison and G. Feng and Y. Dan},
  journal={Nature neuroscience},
  year={2013},
  volume={16},
  pages={1857 - 1863}
}
The basal forebrain provides the primary source of cholinergic input to the cortex, and it has a crucial function in promoting wakefulness and arousal. However, whether rapid changes in basal forebrain neuron spiking in awake animals can dynamically influence sensory perception is unclear. Here we show that basal forebrain cholinergic neurons rapidly regulate cortical activity and visual perception in awake, behaving mice. Optogenetic activation of the cholinergic neurons or their V1 axon… Expand
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