Fast Inactivation of Delayed Rectifier K Conductance in Squid Giant Axon and Its Cell Bodies

@article{Mathes1997FastIO,
  title={Fast Inactivation of Delayed Rectifier K Conductance in Squid Giant  Axon and Its Cell Bodies },
  author={Chris Mathes and Joshua J C Rosenthal and Clay Armstrong and William F. Gilly},
  journal={The Journal of General Physiology},
  year={1997},
  volume={109},
  pages={435 - 448}
}
Inactivation of delayed rectifier K conductance (gk) was studied in squid giant axons and in the somata of giant fiber lobe (GFL) neurons. Axon measurements were made with an axial wire voltage clamp by pulsing to VK (approximately -10 mV in 50-70 mM external K) for a variable time and then assaying available gK with a strong, brief test pulse. GFL cells were studied with whole-cell patch clamp using the same prepulse procedure as well as with long depolarizations. Under our experimental… CONTINUE READING

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