Fast Inactivation in Shaker K+ Channels

@article{Roux1998FastII,
  title={Fast Inactivation in Shaker K+ Channels  },
  author={Michel J. Roux and Riccardo Olcese and Ligia Toro and Francisco Bezanilla and Enrico Stefani},
  journal={The Journal of General Physiology},
  year={1998},
  volume={111},
  pages={625 - 638}
}
Fast inactivating Shaker H4 potassium channels and nonconducting pore mutant Shaker H4 W434F channels have been used to correlate the installation and recovery of the fast inactivation of ionic current with changes in the kinetics of gating current known as "charge immobilization" (Armstrong, C.M., and F. Bezanilla. 1977. J. Gen. Physiol. 70:567-590.). Shaker H4 W434F gating currents are very similar to those of the conducting clone recorded in potassium-free solutions. This mutant channel… CONTINUE READING
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