Fast DNA sequencing by electrical means inches closer

  title={Fast DNA sequencing by electrical means inches closer},
  author={Massimiliano Di Ventra},
The sequencing of the human genome offered a glimpse of future medical practices, where information retrieved from the genome could be harnessed to inform treatment decisions. However, making DNA sequencing accessible enough for widespread use poses a number of challenges. This perspective article traces the progress made in the field so far and looks at how close we may be already to real-life applications. 

Study of Molecular Junctions Metal—DNA—Metal for the DNA Sequencing

The theoretical modeling of ionic, thermionic, and tunnel currents for nanopores with the gold electrodes located in bio-liquids has been carried out and it is shown that both the ionic and thermionic currents are several orders of magnitude weaker than the direct tunneling current.

Interaction dynamics and site-specific electronic recognition of DNA-nicks with 2D solid-state nanopores

Single-stranded breaks in the DNA backbone caused by many endogenous and exogenous agents often lead to double-stranded breaks that are known causes of chromosomal instabilities leading to copious

Surface modification of graphene nanopores for protein translocation.

Ferritin translocation events were reliably observed after the pores were modified with the phospholipid–PEG (DPPE-PEG750) amphiphile, suggesting that a series of interactions between the protein and pores occurs during the process.

Ion age transport: developing devices beyond electronics

This issue provides an overview of voltage-gated ion and molecule transport in engineered nanoch channels in systems that have three or more terminals, similar to metal-oxide-semiconductor field-effect transistors and describes the potential profiles in the nanochannels and the theory behind some of the effects that originate from the nanoscale feature sizes such as ion permselectivity.