Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation.

@article{Giese2014FastBS,
  title={Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation.},
  author={Maria Giese and Johannes Beck and Serge Brand and Flavio Muheim and Ulrich Michael Hemmeter and Martin Hatzinger and Edith Holsboer-Trachsler and Anne Eckert},
  journal={Journal of psychiatric research},
  year={2014},
  volume={59},
  pages={1-7}
}
OBJECTIVE Preclinical and clinical studies support a role for brain-derived neurotrophic factor (BDNF) in the pathophysiology of stress-related mood disorders. Furthermore, BDNF seems to be linked to antidepressant action. Available pharmacological treatments for depression are characterized by significant limitations with low efficacy and a major delay until treatment response. This demonstrates the urgent need for more efficient and fast-acting antidepressants. Besides ketamine, sleep… CONTINUE READING

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