Fast, Approximate Kinetics of RNA Folding

@article{Senter2015FastAK,
  title={Fast, Approximate Kinetics of RNA Folding},
  author={Evan Senter and Peter Clote},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2015},
  volume={22 2},
  pages={
          124-44
        }
}
In this article, we introduce the software suite Hermes, which provides fast, novel algorithms for RNA secondary structure kinetics. Using the fast Fourier transform to efficiently compute the Boltzmann probability that a secondary structure S of a given RNA sequence has base pair distance x (resp. y) from reference structure A (resp. B), Hermes computes the exact kinetics of folding from A to B in this coarse-grained model. In particular, Hermes computes the mean first passage time from the… CONTINUE READING
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