Fasciola hepatica tegumental coat antigen suppresses MAPK signalling in dendritic cells and up-regulates the expression of SOCS3.

@article{Vukman2013FasciolaHT,
  title={Fasciola hepatica tegumental coat antigen suppresses MAPK signalling in dendritic cells and up-regulates the expression of SOCS3.},
  author={Krisztina V. Vukman and Paul N. Adams and Sandra M O'neill},
  journal={Parasite immunology},
  year={2013},
  volume={35 7-8},
  pages={234-8}
}
Fasciola hepatica tegumental coat antigen (FhTeg) suppresses dendritic cell maturation and function by inhibiting IL-6, tumour necrosis factor (TNF)-α, IL-10 and IL-12 production and CD80, CD86 and CD40 cell surface marker expression in TLR4-stimulated dendritic cells. Fasciola hepatica also impairs dendritic cell function by inhibiting its phagocytic… CONTINUE READING