Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis.

  title={Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis.},
  author={Masahide Tone Brady and Sandra M O'neill and John Pius Dalton and Kingston H. G. Mills},
  journal={Infection and immunity},
  volume={67 10},
Fasciolosis, like other helminth infections, is associated with the induction of T-cell responses polarized to the Th2 subtype. Respiratory infection with Bordetella pertussis or immunization with a pertussis whole-cell vaccine (Pw) induces a potent Th1 response, which confers a high level of protection against bacterial challenge. We have used these two pathogens to examine bystander cross-regulation of Th1 and Th2 cells in vivo and provide evidence of immunomodulation of host T-cell responses… CONTINUE READING


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Publications referenced by this paper.
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Immunology of Fasciola hepatica infection, p. 341–376

  • G. Mulcahy, P. Joyce, J. P. Dalton
  • Fasciolosis. CAB International,
  • 1999
1 Excerpt

IL-18 (IFN-g inducing factor) regulates early cytokine production, and promotes the resolution of bacterial infection in mice

  • E. Bohn, A. Sing, +5 authors I. B. Autenriech
  • J. Immunol
  • 1998
1 Excerpt

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