Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis.

@article{Brady1999FasciolaHS,
  title={Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis.},
  author={Masahide Tone Brady and Sandra M O'neill and John Pius Dalton and Kingston H. G. Mills},
  journal={Infection and immunity},
  year={1999},
  volume={67 10},
  pages={5372-8}
}
Fasciolosis, like other helminth infections, is associated with the induction of T-cell responses polarized to the Th2 subtype. Respiratory infection with Bordetella pertussis or immunization with a pertussis whole-cell vaccine (Pw) induces a potent Th1 response, which confers a high level of protection against bacterial challenge. We have used these two pathogens to examine bystander cross-regulation of Th1 and Th2 cells in vivo and provide evidence of immunomodulation of host T-cell responses… CONTINUE READING

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